Buscar
Mostrando ítems 1-10 de 26
Myocardial Alterations in the Murine Model of Fabry Disease Can Be Reversed by Enzyme Replacement Therapy
(Pulsus Group Inc, 2011-05)
Background: Fabry disease results from deficiency of alpha-galactosidase A (AGA), causing lysosomal storage of globotriaosylceramide in heart and other tissues. Since 2003, enzymatic replacement therapy with recombinant ...
Trypanosoma cruzi infection induces the expression of CD40 in murine cardiomyocytes favoring CD40 ligation-dependent production of cardiopathogenic IL-6
(Springer, 2015-11)
The inflammatory response in the myocardium is an important aspect of the pathogenesis of Chagas heart disease raised by Trypanosoma cruzi. CD40, a transmembrane type I receptor belonging to the tumor necrosis factor ...
Thioredoxin-1 Attenuates Ventricular and Mitochondrial Postischemic Dysfunction in the Stunned Myocardium of Transgenic Mice
(Mary Ann Liebert, 2016-07)
Aim: We evaluated the effect of thioredoxin1 (Trx1) system on postischemic ventricular and mitochondrial dysfunction using transgenic mice overexpressing cardiac Trx1 and a dominant negative (DN-Trx1) mutant (C32S/C35S) ...
Diminished Prolinemia in Chronic Chagasic Patients: A New Clue for Disease Pathology?
(MDPI, 2019-08)
Trypanosoma cruzi, the etiological agent of Chagas disease, is dependent on proline for a variety of processes, such as energy metabolism, host cell invasion, differentiation, and resistance to osmotic, metabolic, and ...
New insights into the immunobiology of mononuclear phagocytic cells and their relevance to the pathogenesis of cardiovascular diseases
(Frontiers Media S.A., 2018-01)
Macrophages are the primary immune cells that reside within the myocardium, suggesting that these mononuclear phagocytes are essential in the orchestration of cardiac immunity and homeostasis. Independent of the nature of ...
Activated alpha-2 macroglobulin improves insulin response via lrp1 in lipid-loaded hl-1 cardiomyocytes
(Multidisciplinary Digital Publishing Institute, 2021-06-28)
Activated alpha-2 Macroglobulin (α2M*) is specifically recognized by the cluster I/II of LRP1 (Low-density lipoprotein Receptor-related Protein-1). LRP1 is a scaffold protein for insulin receptor involved in the insulin-induced ...
Glicogenose hereditária em bovinos Brahman no BrasilInherited glycogenosis in Brahman cattle in Brazil
(Revista Pesquisa Veterinaria Brasileira, 2005-12)
An inherited disease of cattle, characterized by lysosomal storage of glycogen in several tissues, is reported. The disease was diagnosed in a Brahman herd in the municipality of Porto Lucena, Rio Grande do Sul, Brazil. ...
HIF‐1α and CD73 expression in cardiac leukocytes correlates with the severity of myocarditis in end‐stage Chagas disease patients
(Federation of American Societies for Experimental Biology, 2021-01)
Chronic Chagas cardiomyopathy is the main infectious myocarditis worldwide. Almost 30% of Trypanosoma cruzi infected individuals develop slow and progressive myocarditis that leads to ventricular dilation and heart failure. ...
Acute heart failure in rabbits by avocado leaf poisoning
(Elsevier, 2019)
The aim of this paper was to report an outbreak of avocado poisoning in rabbits in Salta, Argentina. Fourteen
rabbits died of congestive heart failure within 30 h of ingesting fresh avocado leaves from pruned trees. ...
Metalloproteinase 2 and 9 Activity Increase in Epicardial Adipose Tissue of Patients with Coronary Artery Disease
(Bentham Science Publishers, 2017-01)
Background: Epicardial adipose tissue (EAT) is a visceral adipose tissue (AT) surrounding and infiltrating myocardium and coronary arteries. Increased EAT may represent a chronic inflammatory injury and a link with coronary ...